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pentobarbital will minimize the level or effect of eplerenone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Significance Unknown.Contraindicated (1)pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Sturdy CYP3A4 inducers can lower panobinostat ranges b